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The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice.
- Source :
- Tuberculosis (14729792); Nov2006, Vol. 86 Issue 6, p430-437, 8p
- Publication Year :
- 2006
-
Abstract
- Summary: Mycobacterium tuberculosis genes Rv2557 and Rv2558 have no known function. However, proteome, transcriptome and in situ hybridization studies have shown that these genes are significantly upregulated under carbon-starved conditions and in human granulomas, suggesting that they may play a role in persistence. Single and double deletion mutants of M. tuberculosis H37Rv in Rv2557 and/or Rv2558 were generated to explore their individual and/or collective role(s) in growth and survival. The mutants were assessed for growth and survival in vitro under normal and nutrient-deprived conditions and for virulence in the SCID mouse model. Although highly induced by carbon starvation, loss of Rv2557 and/or Rv2558 affected neither the long-term survival of M. tuberculosis under carbon-starved conditions in vitro, nor its virulence in SCID mice. [Copyright &y& Elsevier]
- Subjects :
- TUBERCULOSIS
MYCOBACTERIAL diseases
LUNG diseases
HEREDITY
GENES
Subjects
Details
- Language :
- English
- ISSN :
- 14729792
- Volume :
- 86
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Tuberculosis (14729792)
- Publication Type :
- Academic Journal
- Accession number :
- 22816082
- Full Text :
- https://doi.org/10.1016/j.tube.2005.11.001