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Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus.
- Source :
- Human Pathology; May2006, Vol. 37 Issue 5, p569-577, 9p
- Publication Year :
- 2006
-
Abstract
- Summary: Claudins are transmembrane proteins that seal tight junctions, bind with peripheral protein zonula occludens (ZO)-1, and are known to play an important role in several normal tissues and cancers. However, the role of claudin-1 and claudin-7 expressions in esophageal squamous cell carcinoma remains to be clarified. In the present study, we confirmed the expressions of claudin-1, claudin-7, and ZO-1 in the prickle cell layer of the normal human esophageal squamous epithelium. The expressions of claudin-1 and claudin-7 at the invasive front of the esophageal squamous cell carcinoma were analyzed immunohistochemically to clarify their role in tumor progression. Reduced expression of claudin-7 at the invasive front of the esophageal cancer was significantly associated with the depth of invasion (P = .004), stage (P = .038), lymphatic vessel invasion (P = .001), and lymph node metastasis (P = .014). In contrast, significant association was not detected between claudin-1 expression and clinicopathologic factors except for histologic differentiation of the tumor (P = .0029). Comparison of claudin-7 expression at the invasive front of the primary tumor and its corresponding metastatic lymph nodes revealed significant reduction in claudin-7 expression in the metastatic lymph nodes (P = .007). These results suggest that the reduced expression of claudin-7 at the invasive front of esophageal squamous cell carcinoma may lead to tumor progression and subsequent metastatic events. Thus, claudin-7 can be a novel marker for the prediction of lymph node metastasis. [Copyright &y& Elsevier]
- Subjects :
- CANCER
PROTEINS
SURGERY
EPITHELIUM
Subjects
Details
- Language :
- English
- ISSN :
- 00468177
- Volume :
- 37
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Human Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 22407845
- Full Text :
- https://doi.org/10.1016/j.humpath.2005.12.018