Findings from Columbia University Medical Center Provide New Insights into Transcription Factors (Microglial Activation Alters Chromatin Accessibility of AD-Associated Transcription Factors).

A recent study from Columbia University Medical Center explores how microglial activation can alter chromatin accessibility of transcription factors associated with Alzheimer's disease (AD). The research suggests that specific inflammatory stimuli can cause epigenetic rewiring in microglia, leading to changes in response to future stimuli and potentially contributing to microglial dysfunction in AD pathogenesis. By analyzing chromatin signatures in response to various stimuli, the study sheds light on the role of innate immune memory in shaping epigenetic modifications in microglia. [Extracted from the article]