Patent Issued for Compositions and methods for treating diseases associated with an imprinting defect (USPTO 12178854).

Children's Medical Center Corporation has been issued a patent for compositions and methods aimed at treating diseases associated with imprinting defects. The patent focuses on activating repressed alleles within imprinting control regions to address imprinting-associated disorders, such as Beckwith-Wiedemann, Angleman, and Prader-Willi syndromes. The methods involve inhibiting histone modifications or selectively removing trimethylation at lysine 27 of histone 3 to treat these disorders. This patent offers potential therapeutic avenues for addressing genomic imprinting-related health issues. [Extracted from the article]