Chromatin Changes Associated with Neutrophil Extracellular Trap (NET) Formation in Whole Blood Reflect Complex Immune Signaling.

The article discusses the formation of neutrophil extracellular traps (NETs) in whole blood and its implications in inflammatory conditions. The study used Assay for Transposase-Accessible Chromatin with sequencing (ATAC-Seq) to analyze chromatin changes during NET formation induced by phorbol 12-myristate 13-acetate (PMA). The research highlights the importance of studying NET formation in a whole blood environment to understand the complexity of immune responses and interactions, which is crucial for identifying therapeutic targets in NET-associated inflammatory diseases. [Extracted from the article]