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Health-reported quality of life in patients with a systemic right ventricle: The Qualisystemic trial.

Health-reported quality of life in patients with a systemic right ventricle: The Qualisystemic trial.

Authors :
Padovani, P.
Werner, O.
Picot, M.-C.
Huguet, H.
Amédro, P.
Source :
Archives of Cardiovascular Diseases; 2025 Supplement, Vol. 118 Issue 1, pS143-S143, 1p
Publication Year :
2025

Abstract

Efforts have been made to improve therapeutic and diagnostic strategies in systemic right ventricles (SRV), one of the most complex congenital heart diseases (CHD). Understanding the determinants of quality of life in these patients could help them to receive more holistic care and improve their daily lives. The aim of the Qualisystemic trial is to evaluate health-related quality of life (HRQoL) and to understand the factors associated with HRQoL in this population. This prospective multicenter cross-sectional study was performed between 2017 and 2020 in 13 congenital heart disease centers from France and Belgium. Adult patients with a D-transposition of the great artery (d-TGA) or a congenitally corrected transposition of the great artery (cc-TGA) were included. Demographic, clinical, laboratory, and imaging data were collected. Ninety-nine adult patients with systemic right ventricle (mean age 38.7 ± 9.2 years; sex ratio of 1.1) with a diagnosis of d-TGA (n = 70) or cc-TGA (n = 27) were included in the analysis. Most patients were symptomatic (52.2% in NYHA II functional class and 33.7% in NYHA III) with impaired exercise capacity (mean VO2max of 20 ± 6.1 mL/kg/min, representing 62.4 ± 16.8% of the predicted values). Physical component of SF36 score was influenced by the VO2max, a recent cardiac decompensation, an unemployed status, and the use of Vitamin K Antagonist (VKA). The number of treatments and the use of antiarrhythmic drugs were correlated with lower psychological component of SF-36. Our study highlights the necessity of a multidisciplinary approach for these complex patients. Cardiovascular exercise rehabilitation, therapeutic education program, and social support should form the cornerstone of their management, complementing medical and technical advancements. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18752136
Volume :
118
Issue :
1
Database :
Supplemental Index
Journal :
Archives of Cardiovascular Diseases
Publication Type :
Academic Journal
Accession number :
182237322
Full Text :
https://doi.org/10.1016/j.acvd.2024.10.274