"Engineered Transposase And Uses Thereof" in Patent Application Approval Process (USPTO 20240425848).

The patent application titled "Engineered Transposase And Uses Thereof" discusses the development of engineered transposases for analyzing chromatin modifications that were previously excluded from sequencing analyses. The inventors have introduced a method called "genome and epigenome by transposases sequencing" (GET-seq) that allows for comprehensive assessment of open and closed chromatin at the single-cell level. This approach aims to provide insights into the dynamic genomic and epigenetic landscapes of single cell populations in physiology and human diseases, offering advantages over conventional techniques such as ChIP-seq and Nextera sequencing. [Extracted from the article]