Soft coral Lobophytum crassum extract inhibits migration and induces apoptosis capabilities in human oral squamous cell carcinoma cells.

The extract of the soft coral Lobophytum crassum has shown an anti-cancer activity in various cancer cells. However, its effect on the oral squamous cell carcinoma cell (OSCC) lines remains unclear. The purpose of this study is to investigate the anti-cancer effects of the extract of L. crassum (C127) on the OSCC cells. This study evaluated the effects of the soft coral extract of L. crassum (C127) on SAS and Ca9-22 cells, cell viability, migration ability, and apoptosis. Electric cell-substrate impedance sensing (ECIS) was parallelly used on SAS cells to confirm the results. C127 affected cell viability, morphology, and migration ability in both cell lines. In SAS cells, C127 inhibited cell viability in a dose dependent manner (P < 0.001) and induced apoptosis at 10 μg/mL (P < 0.05). In addition, C127 significantly inhibited migration ability on both cell lines in a dose-dependent manner (P < 0.001). This study illustrated the potential of marine-derived compounds of L. crassum on its activity against OSCC cells. [ABSTRACT FROM AUTHOR]