KIF18A in HCC Metastasis: Dual Role in Anoikis Resistance and Chromosome Instability.

The article from Cancer Weekly discusses the role of the gene KIF18A in the metastatic progression of hepatocellular carcinoma (HCC). The study highlights how KIF18A is crucial in connecting chromosomal instability (CIN) and anoikis resistance, both significant factors in HCC metastasis. The findings suggest that E2F activation leads to the transcription of KIF18A, promoting tumor survival and metastasis through non-canonical NF-kB activation. The study acknowledges the need for further animal studies to validate the results and explore potential therapeutic implications of targeting KIF18A in cancer treatment. [Extracted from the article]