High-efficiency genomic mapping of chromatin-associated targets with CUT&RUN.

The article discusses the importance of precise regulation of chromatin composition in gene expression and cellular identity, highlighting the use of the CUT&RUN method for high-resolution epigenomic profiling. The approach has been successful in various cell and tissue types, providing valuable insights into genomic distribution with high sensitivity and throughput. The article offers a detailed protocol for CUT&RUN, emphasizing best practices and controls for specific, efficient, and robust target profiling. [Extracted from the article]