Treatment of odontogenic keratocyst with 5-fluorouracil and surgery: Presentation of 3 cases.

Odontogenic keratocyst (OKC) is a lesion that is originated from the dental epithelium, is asymptomatic and can grow large, with a recurrence that varies from 5% to 62%. The antimetabolite 5-fluorouracil (5-FU) has shown less damage to adjacent structures and reduces the recurrence rate. Case 1: A 32-year-old female patient presented due to increased volume, an incisional biopsy was performed, obtaining a diagnosis of OKC, decompression and marsupialization were performed for 18 months, because the lesion had smaller dimensions, enucleation was performed, peripheral osteotomy and application of 5-FU with modified technique. Case 2: A 10-year-old male patient with increased volume in the maxillary region and drainage of fluid into the oral cavity, a biopsy was performed obtaining a diagnosis of OKC, enucleation, peripheral osteotomy, and application of 5-FU for 24 hours were performed, after that time, the surgical dressing was removed and the wound was closed. Case 3: A 15-year-old female patient presented with an increase in volume in the mandibular body on the left side. An incisional biopsy was performed, obtaining a diagnosis of OKC, for which enucleation, peripheral osteotomy, and application of 5-FU with a modified technique were performed. The 5-FU has obtained lower recurrence and damage to structures compared to simple enucleation and Carnoy's solution. With the application of 5-FU with the modified technique, the postoperative period is more comfortable and removal of the dressing after 24 hours is avoided. [ABSTRACT FROM AUTHOR]