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RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway.

Authors :
Xu, Lu
Xie, Zhi-Hao
Li, Jun
Tao, Shi
Ren, Fang-Li
Wang, Yin-Yin
Chang, Zhi-Jie
Hao, Xin-Bao
Source :
Asian Pacific Journal of Tropical Biomedicine; Jul2024, Vol. 14 Issue 7, p307-317, 11p
Publication Year :
2024

Abstract

Objective: To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma (DLBCL) and its potential as a therapeutic target. Methods: This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival analysis. In vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and apoptosis. Results: RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor prognosis. In vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling pathway. Conclusions: RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular proliferation. Targeting RPRD1B may offer a novel therapeutic strategy for DLBCL, suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22211691
Volume :
14
Issue :
7
Database :
Supplemental Index
Journal :
Asian Pacific Journal of Tropical Biomedicine
Publication Type :
Academic Journal
Accession number :
181418203
Full Text :
https://doi.org/10.4103/apjtb.apjtb_172_24