Studies from Islamic Azad University Reveal New Findings on Anxiety Disorders (Norharmane Potentiated Anxiolytic- and Antidepressant-like Responses Induced By Imipramine and Citalopram: an Isobologram Analysis).

A study conducted at Islamic Azad University in Tehran, Iran, explored the effects of norharmane, imipramine, and citalopram on anxiety and depression behaviors in male mice. The research found that norharmane, imipramine, and citalopram all exhibited anxiolytic and antidepressant-like effects, with norharmane potentiating the responses induced by imipramine and citalopram. The study concluded that there were additive anxiolytic and antidepressant-like effects between norharmane and these antidepressant drugs in modulating anxiety and depression processes in mice. [Extracted from the article]