Reports Outline Life Science Findings from Virginia Commonwealth University (Spatial Transcriptomics Unravels Palmitoylation and Zonation-dependent Gene Regulation By Aeg-1 In Mouse Liver).

Researchers at Virginia Commonwealth University conducted a study on the role of AEG-1 in promoting metabolic dysfunction and liver diseases like MASH and HCC. They found that palmitoylation of AEG-1 influences gene regulation in different zones of the liver, leading to activation of pro-inflammatory pathways in specific hepatocytes. The study highlights the importance of understanding how gene regulation in different liver zones contributes to metabolic dysfunction and liver diseases. For more information, readers can refer to the Journal of Biological Chemistry. [Extracted from the article]