Reports Summarize Liver Cancer Research from Seoul National University College of Medicine (Establishment and characterization of mouse metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma organoids).

Researchers from Seoul National University College of Medicine have established and characterized mouse organoids to study metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma (HCC) and drug responses, particularly focusing on Lenvatinib resistance. The study found that multi-biotics, a fermented product, enhanced the response to Lenvatinib in HCC models, despite not reducing tumor burden. Transcriptomic analysis of drug-resistant organoids identified key pathways related to KRAS signaling, inflammation, and epithelial-mesenchymal transition (EMT), providing insights into potential targets for overcoming Lenvatinib resistance in MASH-related HCC. This research offers a valuable model for further therapeutic studies in liver cancer treatment. [Extracted from the article]