Computational design of Bax-inhibiting peptides.

The article discusses the computational design of Bax-inhibiting peptides, which target a proapoptotic protein called Bax to regulate apoptotic signaling. By using rational design and computer simulations, researchers have developed peptides that bind to Bax with high affinity, potentially offering new therapeutic approaches for cancer and neurodegenerative diseases. The designed peptides modulate specific sites associated with toxicity, showing promise in modulating apoptotic pathways and laying the groundwork for further exploration in peptide design. [Extracted from the article]