Investigators from Department of Chemical and Forensic Sciences Target Central Nervous System Agents (Kinetic Spectrophotometric Determination of Memantine Hydrochloride Based On the Formation of Its Dinitrochlorobenzene Adduct).

Researchers from the Department of Chemical and Forensic Sciences in Gujarat, India, have developed a new method for accurately determining memantine hydrochloride using kinetic spectroscopy. The method involves measuring the reaction between the drug and 1-chloro-2,4-dinitrobenzene in an alkaline medium at 70 degrees C, resulting in a distinctive absorbance peak at 290.5 nm. The study was supported by the Education Department of the Government of Gujarat, and the researchers were able to effectively determine memantine hydrochloride in a commercial formulation. The research has been peer-reviewed and published in the Journal of Analytical Chemistry. [Extracted from the article]