11476 Association of Pre-Operative NLR (Neutrophil-to-Lymphocyte Ratio) With Disease Severity in Surgically Managed Endometriosis.

To determine whether pre-operative neutrophil-to-lymphocyte ratio (NLR) correlates with endometriosis severity in patients with pathology-confirmed endometriosis surgically staged by MIGS providers at our institution using the 2021 American Association of Gynecologic Laparoscopists (AAGL) endometriosis classification system. Retrospective chart review of all patients who underwent primary surgery for endometriosis between January 2018 and December 2023 at Stony Brook University Hospital with pathology-confirmed endometriosis. Large academic medical center in Long Island, New York. All patients who underwent primary surgery for endometriosis in the study time period with pathology-confirmed endometriosis. Patients with comorbidities or medication use that affect systemic inflammation (i.e. malignancy, active infection, autoimmune and hematological disorders) were excluded from the study. Demographic data, clinical history, and pre-operative bloodwork were retrospectively recorded. Using operative findings and pathology reports, all patients were staged according to the 2021 AAGL endometriosis classification system. Thus far, we have collected data and performed statistical analysis on 77 patients who met inclusion criteria. Our preliminary analysis of variance and Mood's median tests find statistically significant differences in NLR across stages 1 through 3 (p<0.05). Our preliminary data suggest that pre-operative NLR correlates positively with surgical stage of endometriosis. Therefore, NLR may be a useful prognostic marker in endometriosis and may aid in predicting surgical complexity pre-operatively. Data collection is ongoing in order to reach statistical power. [ABSTRACT FROM AUTHOR]