Kagawa University Researchers Advance Knowledge in Alzheimer Disease [Association between Polypharmacy and Adverse Events in Patients with Alzheimer's Disease: An Analysis of the Japanese Adverse Drug Event Report Database (JADER)].

Researchers from Kagawa University in Japan conducted a study on the association between polypharmacy and adverse events in patients with Alzheimer's disease. The study analyzed data from the Japanese Adverse Drug Event Report database from 2004 to 2020 and found that polypharmacy was significantly correlated with an increased incidence of adverse events, such as altered state of consciousness, decreased appetite, vomiting, and falls. The research concluded that the occurrence of adverse events in Alzheimer's disease treatment is linked to the number of concurrent medications, regardless of the known adverse effects of specific drugs or their combination patterns. [Extracted from the article]