Somatic Mutations in MCOLN3 in Aldosterone-Producing Adenomas cause Primary Aldosteronism.

The article discusses a study on primary aldosteronism, a condition characterized by renin-independent hyperaldosteronism originating from aldosterone-producing lesions in the adrenal glands. Researchers identified somatic mutations in MCOLN3 in aldosterone-producing adenomas (APAs) in male patients with primary aldosteronism, suggesting a potential role of mutated MCOLN3 in driving aldosterone excess. The study highlights the importance of understanding genetic factors in the regulation of aldosterone production in primary aldosteronism. [Extracted from the article]