An increase in reactive oxygen species underlies neonatal cerebellum repair.

The article discusses a study on the regenerative potential of the neonatal mouse cerebellum following injury at birth. The research focuses on how reactive oxygen species (ROS) play a role in the adaptive reprogramming of Nestin-expressing progenitors (NEPs) to replenish granule cell progenitors. The study also highlights the involvement of microglia in regulating NEP replenishment, emphasizing the importance of the tissue microenvironment in the regeneration of the neonatal brain. This preprint has not yet undergone peer review. [Extracted from the article]