Studies from Wuhan University Further Understanding of Acute Kidney Injury [Inhibition of Mitochondrial Over-division By (+)-14,15-dehydrovincamine +)-14,15-dehydrovincamine Attenuates Cisplatin-induced Acute Kidney Injury Via the Jnk/mff...].

A study conducted at Wuhan University in China focused on the use of (+)-14,15-dehydrovincamine to mitigate cisplatin-induced acute kidney injury (AKI) by targeting the JNK/Mff pathway. The research highlighted the compound's ability to reduce mitochondrial fission, maintain mitochondrial homeostasis, and attenuate apoptosis in renal tubular epithelial cells. This study sheds light on potential therapeutic agents for AKI treatment and was supported by the National Natural Science Foundation of China and the China Postdoctoral Science Foundation. [Extracted from the article]