Post-transcriptional regulation of cyclin A and cyclin B mRNAs is mediated by Bruno 1 and Cup, and further fine-tuned within P-bodies.

The article discusses the post-transcriptional regulation of cyclin A and cyclin B mRNAs by Bruno 1 and Cup, as well as their association with P-bodies. The study demonstrates that depletion of these proteins leads to abnormal protein expression and reduced mRNA levels for both Cyclins. The research highlights the nuanced, mRNA-specific roles of P-body condensates in post-transcriptional regulation, challenging the idea of a uniform mechanism of mRNA repression in P-bodies. [Extracted from the article]