Research from University of Pennsylvania Reveals New Findings on Cancer (Abstract A046: Tissue-of-origin determines immune cell heterogeneity and response to therapy via unique tumor cell-intrinsic factors).

Research from the University of Pennsylvania explores the impact of tissue-of-origin on immune cell heterogeneity and response to therapy in cancer. The study reveals that tumors from different tissues exhibit varying immune cell infiltration, affecting their sensitivity to immunotherapy. By analyzing clonal cell lines from lung and pancreatic cancers, researchers found tissue-specific differences in immune phenotype and therapy response, potentially influenced by somatic copy number alterations. The findings suggest the importance of understanding tumor cell-intrinsic factors to enhance therapy outcomes in a tissue-specific manner. [Extracted from the article]