Investigators at Purdue University Discuss Findings in Biologics [Engineered Polymeric Excipients for Enhancing the Stability of Protein Biologics: Poly(N-isopropylacrylamide)-poly(Ethylene Glycol) (Pnipam-peg) Block Copolymers].

Researchers at Purdue University have identified poly(N-isopropylacrylamide)-poly(ethylene glycol) (PNIPAM-PEG) block copolymers as a promising alternative to polysorbates for enhancing the stability of protein biologics. The study found that PNIPAM-PEG outperforms polysorbates in preserving IgG stability against surface-induced aggregation, particularly under high-temperature conditions. This research, funded by the National Science Foundation and Purdue University Institute for Cancer Research, highlights the potential of PNIPAM-PEG as an excipient for antibody therapeutics, contributing to the development of more stable and effective biopharmaceuticals. [Extracted from the article]