Network mechanisms in rapid-onset dystonia-parkinsonism.

The article discusses rapid-onset dystonia-parkinsonism (RDP), a rare neurological disorder caused by mutations in the ATP1A3 gene. Experimental studies suggest that the pathophysiology of RDP involves dysfunction in the cerebellum, basal ganglia, and motor cortex. The study aimed to characterize neuronal network activity in these areas using an ouabain model in rats, revealing specific oscillations associated with dystonia and parkinsonism. This preprint has not been peer-reviewed and provides valuable insights into the network mechanisms underlying RDP. [Extracted from the article]