Findings from Virginia Commonwealth University Update Understanding of Anaplasma phagocytophilum (anaplasma Phagocytophilum Invasin Aipa Interacts With Cd13 To Elicit Src Kinase Signaling That Promotes Infection).

Researchers at Virginia Commonwealth University have made significant findings regarding Anaplasma phagocytophilum, a Gram-Negative Bacteria that causes granulocytic anaplasmosis by invading neutrophils. The study identified that the AipA protein of A. phagocytophilum interacts with CD13 to induce Src kinase signaling, facilitating the bacterium's entry into host cells. This interaction was found to be crucial for infection in vivo, highlighting the importance of CD13 in microbial infection. The research sheds light on the mechanisms underlying host-microbe interactions and the pathogenesis of A. phagocytophilum. [Extracted from the article]