Findings from Southwest University Broaden Understanding of Streptococcus suis (RACK1 and NEK7 mediate GSDMD-dependent macrophage pyroptosis upon Streptococcus suis infection).

A recent study conducted by researchers at Southwest University has shed light on the mechanism behind Streptococcus suis-induced macrophage pyroptosis. Streptococcus suis serotype 2 (SS2) is a zoonotic pathogen that triggers an NLRP3-dependent cytokine storm, leading to inflammation and pyroptosis. The study found that SS2 induces pyroptosis through the activation of the NLRP3-GSDMD pathway, with RACK1 and NEK7 playing important roles in this process. These findings provide new insights into SS2-induced cell death. [Extracted from the article]