New Bone Research Research from University of Paris Est Creteil Outlined (Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma).

A recent report from the University of Paris Est Creteil highlights the role of immune cells, specifically macrophages, in bone repair and the treatment of musculoskeletal trauma. The study found that macrophages play a crucial role in the inflammatory response and the modulation of skeletal stem/progenitor cells during bone fracture healing. The researchers also discovered distinct subsets of macrophages with different profiles, including pro-inflammatory, pro-repair, and anti-inflammatory. In a preclinical mouse model, the depletion of macrophages improved bone regeneration, and pharmacological inhibition of macrophages showed promising results in healing. These findings suggest that targeting macrophages could be a potential therapeutic strategy for trauma-associated fibrosis. [Extracted from the article]