Phospholipase D3 regulates TFEB/TFE3 metabolism to maintain lysosomal homeostasis.

A preprint abstract from biorxiv.org discusses the role of Phospholipase D3 (PLD3) in Alzheimer's disease (AD). The study found that a coding variant in PLD3 increases the risk of AD. PLD3 is a lysosomal protein, and its deficiency leads to lysosomal abnormalities and an increase in TFEB/TFE3 levels, nuclear translocation, and transcriptional activities. The findings suggest that PLD3 is involved in regulating lysosomal biogenesis via TFEB/TFE3 signaling, and lysosomal abnormalities resulting from PLD3 deficiency may be a risk factor for AD. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]