Researchers from Fourth Military Medical University Describe Findings in Nanocomposites (Treatment Effects of 3d-printed Pcl/fe3o4@ 3 O 4 @ Zif-8 Magnetic Nanocomposite On Infected Bone Defect).

A study conducted by researchers from the Fourth Military Medical University in Shaanxi, China, explores the treatment of infected bone defects using a novel magnetic nanocomposite. The researchers developed a 3D-printed PCL/Fe3O4@ZIF-8 nanocomposite scaffold that exhibited good biocompatibility, antibacterial activity, and osteogenic ability. The scaffold promoted the proliferation and adhesion of bone marrow mesenchymal stem cells and upregulated the expression of osteogenic-related genes and proteins. In vivo experiments demonstrated that the scaffold eliminated infection and promoted new bone formation. The study suggests that the 3D-printed nanocomposite scaffold could be a promising material for the treatment of infected bone defects. [Extracted from the article]