Study Findings on Antimicrobials Described by Researchers at Misr University for Science and Technology (Discovery of Benzopyrone-Based Candidates as Potential Antimicrobial and Photochemotherapeutic Agents through Inhibition of DNA Gyrase...).

A study conducted at Misr University for Science and Technology has discovered potential antimicrobial agents that inhibit bacterial DNA gyrase, an enzyme considered a validated target for antibacterial drug discovery. The researchers designed and synthesized twenty-two benzopyrone-based derivatives with different chemical features and evaluated their antimicrobial and photosensitizing activities. Several compounds showed promising results against bacterial strains, and in silico molecular docking and in vitro DNA gyrase supercoiling inhibitory assays were performed to study their mechanisms of action. Compound 8d exhibited the most potent inhibitory activity and could serve as a foundation for future research on DNA gyrase inhibition with antibacterial activity. [Extracted from the article]