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To sense or not to sense, Paneth cell regulation of mucosal immunity.
- Source :
- Cell Host & Microbe; Oct2024, Vol. 32 Issue 10, p1648-1650, 3p
- Publication Year :
- 2024
-
Abstract
- Paneth cells located within intestinal crypts support epithelial stem cells and immunity through growth factors and antimicrobial peptides. In this issue of Cell Host & Microbe , Wallaeys et al. report that TNF sensing by Paneth cells disrupts the unfolded protein response and decreases antimicrobial peptides, causing bacterial translocation and sepsis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19313128
- Volume :
- 32
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Cell Host & Microbe
- Publication Type :
- Academic Journal
- Accession number :
- 180132585
- Full Text :
- https://doi.org/10.1016/j.chom.2024.09.005