Comprehensive Mutational Landscape Analysis of Monkeypox Virus Proteome.

A recent article in Vaccine Weekly discusses a comprehensive computational analysis of the mutational landscape of the Monkeypox virus (MPXV) proteome. The study reconstructed the mutational landscapes of 171 MPXV proteins using advanced mutational effect predictors and evaluated the predicted structures with various metrics. The researchers identified several mutation-sensitive proteins, including membrane-associated proteins that are important for viral interactions with hosts. This analysis provides valuable information for assessing the impact of new MPXV variants and guiding therapeutic strategies. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]