Investigators at University of Minnesota Detail Findings in Tissue Engineering (hdac3 Deficiency Limits Periosteal Reaction Associated With Western Diet Feeding In Female Mice).

A recent report from the University of Minnesota discusses the findings of a study on tissue engineering and bone regeneration. The researchers focused on the effects of a high-fat/high-sugar diet on bone healing and the potential anti-inflammatory properties of HDAC inhibitors. The study found that mice with HDAC3 deficiency showed enhanced intramembranous bone healing and reduced periosteal reaction tissue when fed a high-fat/high-sugar diet. The researchers also observed increased production of the chemokine CCL2 in HDAC3-deficient mice, which may contribute to the improved bone healing. This research provides insights into the potential role of HDAC3 in bone regeneration and the impact of diet-induced obesity on bone healing. [Extracted from the article]