Researchers from F. Hoffmann-La Roche Ltd. Describe Findings in Biologics (Reversible Protein Complexes: Advancing Subcutaneous Delivery With Controlled and Sustained Release of High Concentration Biologics).

Researchers from F. Hoffmann-La Roche Ltd. in Basel, Switzerland have conducted a study on high concentration formulations of biologics for subcutaneous administration. They used a reversible protein complex (RPC) approach and a novel in vitro tool called the Subcutaneous Injection Site Simulator (Scissor) to evaluate the fate and behavior of these formulations. The Scissor simulates the changes that a biological drug could encounter as it transitions from a drug product formulation to the hypodermis following subcutaneous injection. The study found that the Scissor can provide a suitable tool to predict the stability of biological drugs in the subcutaneous environment, and in vitro drug release data showed sustained and controlled release of RPC formulations. This research has been peer-reviewed and published in the Journal of Drug Delivery Science and Technology. [Extracted from the article]