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Findings from Wuhan University Broaden Understanding of Cancer (Construction of Drug-free Sodium Bicarbonate Nanoparticles With High Water-tolerance for Gas Therapy To Selectively Induce Non-apoptotic Death of Cancer Cells).
- Source :
- Drug Week; 10/8/2024, p601-601, 1p
- Publication Year :
- 2024
-
Abstract
- A study conducted at Wuhan University in China has explored the development of drug-free nanotherapeutics for cancer treatment. The researchers focused on using sodium bicarbonate nanoparticles to selectively induce non-apoptotic death in cancer cells through carbon dioxide-induced lysosomal rupture. The study found that this gas therapy approach resulted in cell death through necrosis, pyroptosis, and ferroptosis, rather than the conventional apoptosis pathway. The high water-solubility of sodium bicarbonate presented a challenge, but the researchers developed a water-tolerant nanoplatform that showed promising results in targeting and inhibiting tumors. This research may also provide insights into developing water-tolerant nanoparticles derived from water-soluble inorganic salts. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 15316440
- Database :
- Supplemental Index
- Journal :
- Drug Week
- Publication Type :
- Periodical
- Accession number :
- 180073517