Findings from Wuhan University Broaden Understanding of Cancer (Construction of Drug-free Sodium Bicarbonate Nanoparticles With High Water-tolerance for Gas Therapy To Selectively Induce Non-apoptotic Death of Cancer Cells).

A study conducted at Wuhan University in China has explored the development of drug-free nanotherapeutics for cancer treatment. The researchers focused on using sodium bicarbonate nanoparticles to selectively induce non-apoptotic death in cancer cells through carbon dioxide-induced lysosomal rupture. The study found that this gas therapy approach resulted in cell death through necrosis, pyroptosis, and ferroptosis, rather than the conventional apoptosis pathway. The high water-solubility of sodium bicarbonate presented a challenge, but the researchers developed a water-tolerant nanoplatform that showed promising results in targeting and inhibiting tumors. This research may also provide insights into developing water-tolerant nanoparticles derived from water-soluble inorganic salts. [Extracted from the article]