Findings from Southwest Medical University in Ophthalmic Preparations Reported (Cellulose Based Molecularly Imprinted Polymer By Hydroxyl Functional Allocation Strategy With Dual Selectivity of Boric Acid Affinity and Molecular Structure...).

A recent report from Southwest Medical University in Sichuan, China discusses the development of a novel magnetic porous cellulose molecularly imprinted polymer (B-MPCMIP) for the selective enrichment and detection of bortezomib, a drug used in the treatment of multiple myeloma. The B-MPCMIP demonstrated dual selectivity towards bortezomib through boric acid affinity and molecular structure limitation. The polymer exhibited good adsorption capacity, fast adsorption effect, and excellent selectivity towards bortezomib. The B-MPCMIP was also successfully used to enrich and detect bortezomib and its metabolites in mouse plasma and liver. The research provides valuable insights into the metabolism of bortezomib and offers a potential method for its analysis. [Extracted from the article]