Reports Outline Myelin Basic Protein Study Results from Southwest Medical University (Ginsenoside Rg1 Protects the Blood-brain Barrier and Myelin Sheath To Prevent Postoperative Cognitive Dysfunction In Aged Mice).

A study conducted at Southwest Medical University in Sichuan, China, explored the effects of ginsenoside Rg1 on postoperative cognitive dysfunction (POCD) in aged mice. The researchers established a POCD mouse model and observed changes in inflammation, blood-brain barrier permeability, and myelin sheath. They found that ginsenoside Rg1 pretreatment improved cognitive function, reduced inflammation, prevented blood-brain barrier leakage, and reversed the downregulation of certain proteins related to myelin sheath and the Wnt pathway. The study suggests that ginsenoside Rg1 may protect the blood-brain barrier and myelin sheath, potentially improving postoperative cognitive function in aged mice. [Extracted from the article]