MITF Targets in Gastrointestinal Stromal Tumors: Implication in Autophagy and Extracellular Vesicle Secretion.

A preprint abstract from biorxiv.org discusses the role of Microphthalmia-associated Transcription Factor (MITF) in regulating Gastrointestinal Stromal Tumors (GIST). The study used Chromatin Immunoprecipitation and RNA sequencing to identify MITF-modulated genes in GIST. The findings suggest that MITF regulates genes involved in lysosome biogenesis, vesicle generation, autophagy, and mTOR signaling pathways. The study also found that MITF overexpression increases autophagy and that silencing MITF disrupts autophagosome and autolysosome formation. The researchers suggest that MITF is a crucial target for managing tumor growth and metastasis in GIST. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]