Correlation between interleukin-6, HMGB-1, and neutrophil-to-lymphocyte ratio to acute respiratory distress syndrome.

Background: Acute respiratory distress syndrome (ARDS) has a high mortality rate if not diagnosed and treated promptly. Several markers could increase during ARDS, such as interleukin 6 (IL-6), high mobility group box-1 (HMGB-1), and neutrophil-to-lymphocyte ratio (NLR). This study aimed to determine the correlation between these markers and the severity of ARDS. Methods: This cross-sectional study was conducted at Dr. Wahidin Sudirohusodo General Hospital from January to April 2024. The population included in this study consisted of all patients treated in the Intensive Care Unit (ICU) and divided into two groups: ARDS and non-ARDS. IL-6, HMGB-1, and NLR were measured once during treatment. The severity assessment was conducted using the Berlin criteria (mild, moderate, severe) for ARDS patients. Results: A total of 30 patients were divided equally into two groups. Mean IL-6 levels were higher in ARDS patients (21.15±3.89) than in non-ARDS (12.56±3.08) with a significant difference (p=0.000). The mean HMGB-1 levels were also higher in ARDS (26.46±30.14) than in non- ARDS (9.37±4.23), with a significant difference (p=0.040). IL-6 (p=0.000) and HMGB-1 (p=0.026) were also significantly associated with ARDS severity. Conclusion: IL-6 and HMGB-1 are related to ARDS severity. [ABSTRACT FROM AUTHOR]