New Medullary Thyroid Cancer Study Findings Recently Were Reported by Researchers at University of Colorado (MEN2 phenotype in a family with germline heterozygous rare RET K666N variant).

A recent report from the University of Colorado discusses new findings on medullary thyroid cancer (MTC), a hereditary cancer syndrome caused by germline-activating pathogenic variants in the RET proto-oncogene. The report focuses on the specific RET germline heterozygous variant K666N, which has been described in very few families. The researchers highlight the need for further understanding of the pathogenicity of this variant and the appropriate screening and treatment for asymptomatic carriers. The report includes a case study of a patient with the RET K666N variant who experienced cardiogenic shock and multi-organ failure. [Extracted from the article]