Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) underlies daily mitochondrial lysine-malonylation and hepatic metabolism.

A preprint abstract from biorxiv.org discusses the role of Acyl-CoA synthetase 3 (ACSF3) in regulating daily hepatic metabolism and lysine-malonylation. The study suggests that circadian rhythms and feeding rhythms are important in maintaining metabolic homeostasis in the liver. The researchers found that ACSF3 expression and its impact on lysine-malonylation are rhythmic and influenced by feeding rhythms. While hepatic ACSF3 knockdown did not affect diet-induced metabolic abnormalities, it was found to play a role in the diurnal regulation of liver glycogen storage, de novo lipogenesis, and triglyceride synthesis. It is important to note that this preprint has not yet undergone peer review. [Extracted from the article]