New Findings on Life Science Described by Investigators at Leiden University (Bimodal Substrate Binding In the Active Site of the Glycosidase Bcx).

Researchers at Leiden University in the Netherlands have made new findings in the field of Life Science. They have studied the Bacillus circulans xylanase (BcX) enzyme, which degrades xylan through a retaining, double-displacement mechanism. The researchers found that the enzyme has a large, active site cleft that allows for the binding of six xylose units. They also discovered that the substrate xylotriose can bind to multiple sites on the enzyme's surface. The research suggests that the interactions with the different active site locations are largely independent of each other. This study was supported by the Dutch Research Council. [Extracted from the article]