Research from David Geffen School of Medicine University of California Los Angeles (UCLA) Yields New Data on Liver Function (The Role of RNA Splicing in Liver Function and Disease: A Focus on Metabolic Dysfunction-Associated Steatotic Liver...).

A new report discusses research findings on liver function, specifically focusing on the role of RNA splicing in metabolic dysfunction-associated steatotic liver disease (MASLD). RNA splicing is a crucial mechanism for gene expression and proteomic diversity. The review explores the regulation of RNA splicing in the liver and its impact on metabolic balance, detoxification, and protein synthesis. It also highlights how dysregulation of splicing can lead to liver diseases such as MASLD and discusses potential therapeutic approaches using antisense oligonucleotides (ASOs) to correct splicing errors. The dysregulation of splicing in liver diseases may also serve as a potential diagnostic marker for early identification of individuals at risk. [Extracted from the article]