How aging affects stem cells: A fly's tale.

Scientists from the RIKEN Center for Biosystems Dynamics Research have discovered key changes in chromosome structure and gene expression that affect stem cell function during aging. Using fruit flies, they found that these changes led to stem cell exhaustion, which prevents stem cells from multiplying. This research provides evidence of an independent exhaustion signal and enhances our understanding of how the delicate balance between stem cell exhaustion and proliferation is disrupted in normal aging. The findings could offer valuable insights into the aging process and how it impacts stem cells in humans. [Extracted from the article]