Distinct functional domains of Dystroglycan regulate inhibitory synapse formation and maintenance in cerebellar Purkinje cells.

This article discusses the role of Dystroglycan, a cell adhesion molecule, in inhibitory synapse formation and maintenance in cerebellar Purkinje cells. The study found that Dystroglycan is necessary for the development and function of synapses between cerebellar molecular layer interneurons and Purkinje cells. The researchers also discovered that both extracellular and intracellular interactions of Dystroglycan are required for synapse function, while only extracellular interactions are necessary for synapse formation. These findings provide molecular insights into the mechanisms of inhibitory synapse formation and maintenance in the cerebellar cortex. [Extracted from the article]