New Purinergic P1 Receptors Findings from University of Southern Santa Catarina Described (Analgesia By Fascia Manipulation Is Mediated By Peripheral and Spinal Adenosine A1 Receptor In a Mouse Model of Peripheral Inflammation).

A recent study conducted by researchers at the University of Southern Santa Catarina in Palhoca, Brazil, explored the role of adenosine A1 receptors in the analgesic effects of fascia manipulation. The study used a mouse model of peripheral inflammation and found that plantar fascia manipulation (PFM) inhibited mechanical hyperalgesia induced by inflammation. The antihyperalgesic effect of PFM was mediated by adenosine receptors, and the involvement of the A1 receptor subtype was confirmed using a selective antagonist. The study suggests that further research is needed to understand the interaction between fascia manipulation and caffeine, which inhibits the antihyperalgesic effect of PFM. [Extracted from the article]