New Avian Leukosis Virus Study Findings Has Been Reported by a Researcher at Yangzhou University (RNA-Seq Analysis of Glycolysis Regulation of Avian Leukosis Virus Subgroup J Replication).

A recent study conducted by researchers at Yangzhou University in China investigated the effect of glycolysis on the replication of Avian Leukosis Virus (ALV-J) in DF1 cells. The study found that glucose uptake, pyruvate content, and lactate content increased in ALV-J-infected cells. Inhibiting glycolysis reduced the replication of the virus. RNA-seq analysis identified differentially expressed circular RNAs (circRNAs) that may be involved in regulating the replication of ALV-J. Functional enrichment analysis suggested that these circRNAs may influence pathways such as glycolysis/gluconeogenesis, NOD-like receptor signaling, MAPK signaling, p53 signaling, Toll-like receptor signaling, insulin signaling, and apoptosis. This study provides insights into the factors influencing ALV-J replication and may contribute to reducing infection rates in poultry. [Extracted from the article]