Research from Kyungpook National University in the Area of Diterpenes Described (Inhibition of Soluble Epoxide Hydrolase by Cembranoid Diterpenes from Soft Coral Sinularia maxima : Enzyme Kinetics, Molecular Docking, and Molecular...).

Researchers from Kyungpook National University in South Korea have discovered that certain compounds found in the soft coral Sinularia maxima have the potential to inhibit soluble epoxide hydrolase (sEH), an enzyme involved in converting epoxy fatty acids into their dihydroxy forms. These compounds, known as cembranoid diterpenes, were found to exhibit significant sEH inhibition, making them potential therapeutic agents for managing cardiovascular and inflammatory diseases. In silico approaches, including molecular docking and molecular dynamics simulations, confirmed the stability and interactions of these compounds with sEH. This research highlights the potential of natural sources, particularly marine environments, in identifying sEH inhibitors with therapeutic applications. [Extracted from the article]